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240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5

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To overcome ROS-induced damage, both the host and pathogen developed antioxidant systems to quench excess ROS (Barna et al., Botrytis cinerea , causing the gray mold disease of plants (Veloso and van Kan, 2018)